Lewis Baker, Department of Applied Mathematics, ذكذكتسئµ Inference of Diffusion Coefficients from Single Particle Trajectories Membrane-targeting proteins are understood to diffuse on the surface of cells and occasionally associate with macromolecules integrated in the cell membrane. This association initiates reaction cascades within the cell, while introducing a drag-like effect on the membrane-targeting protein. In this talk I will present a Hidden Markov Model that characterizes this phenomenon as a switch-diffusion process and present an MCMC parameter estimation scheme to infer the underlying chemical observables of the system (as well as the accompanying analytical and computational challenges of doing so).