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Flaviviruses such as dengue encode a protease that is essential for viral replication. The protease functions by cleaving well-conserved positions in the viral polyprotein. In addition to the viral polyprotein, the dengue protease cleaves at least

Historically, the evolution of bats has been analyzed using a small number of genetic loci for many species or many genetic loci for a few species. Here we present a phylogeny of 18 bat species, each of which is represented in 1,107 orthologous gene

Pandemic HIV-1 (group M) emerged following the cross-species transmission of a simian immunodeficiency virus from chimpanzees (SIVcpz) to humans. Primate lentiviruses (HIV/SIV) require the T cell receptor CD4 to enter into target cells. By surveying

RNA viruses are a major source of emerging and re-emerging infectious diseases around the world. We developed a method to identify RNA viruses that is based on the fact that RNA viruses produce double-stranded RNA (dsRNA) while replicating.

Sawyer Lab, BioFrontiers Institute, ÐßÐßÊÓƵ ÐßÐßÊÓƵ researchers studying virus spillover have uncovered a clue explaining why dengue viruses reach high concentrations in humans, but not in primates,

NIH’s awards support groundbreaking approaches to HIV prevention and treatmentWith diverse proposals focused on everything from natural killer cells to therapeutic vaccines to treat HIV, three recipients have been selected for the 2018 Avant-Garde

Sawyer Lab, BioFrontiers Institute, ÐßÐßÊÓƵ ÐßÐßÊÓƵ researchers studying the emergence of viruses from wildlife populations provide a key clue to how simian immunodeficiency virus emerged from monkeys,

ÌýFor billions of years, the battle between cells and viruses has been a primary driver of evolution. ÐßÐßÊÓƵ researcher Dr. Sara Sawyer has dedicated her career to this relationship, combining methods from virology and

Just as flu season swings into full gear, researchers from the ÐßÐßÊÓƵ and University of Texas at Austin have uncovered a previously unknown mechanism by which the human immune system tries to battle the influenza A virus. The